相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Alzheimer's disease: experimental models and reality
Eleanor Drummond et al.
ACTA NEUROPATHOLOGICA (2017)
Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway
V. Palomera-Avalos et al.
MOLECULAR NEUROBIOLOGY (2017)
SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms
Ruben Corpas et al.
MOLECULAR NEUROBIOLOGY (2017)
Protective effect of resveratrol against inflammation, oxidative stress and apoptosis in pancreas of aged SAMP8 mice
Cristina Gines et al.
EXPERIMENTAL GERONTOLOGY (2017)
MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2
Y. Tang et al.
GENETICS AND MOLECULAR RESEARCH (2017)
Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
Ainhoa Plaza-Zabala et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
The Effects of LW-AFC on the Hippocampal Transcriptome in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer's Disease
Jianhui Wang et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Mouse Models of Alzheimer's Disease
Gisela Esquerda-Canals et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease
Eric Tonnies et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Oxidative Stress and Amyloid Toxicity: Insights From Yeast
Mauro B. Franca et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Cellular cholesterol homeostasis and Alzheimer's disease
Ta-Yuan Chang et al.
JOURNAL OF LIPID RESEARCH (2017)
Brain aging and neurodegeneration: from a mitochondrial point of view
Amandine Grimm et al.
JOURNAL OF NEUROCHEMISTRY (2017)
Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis
Eva Bagyinszky et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)
HDAC inhibitors: A new promising drug class in anti-aging research
Elena G. Pasyukova et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2017)
MicroRNAs in brain aging
Chand Parvez Danka Mohammed et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2017)
Mitophagy in neurodegeneration and aging
Elayne M. Fivenson et al.
NEUROCHEMISTRY INTERNATIONAL (2017)
SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions
Ichiro Akiguchi et al.
NEUROPATHOLOGY (2017)
Proinsulin protects against age-related cognitive loss through anti-inflammatory convergent pathways
Ruben Corpas et al.
NEUROPHARMACOLOGY (2017)
Autophagy Activation Alleviates Amyloid-β-Induced Oxidative Stress, Apoptosis and Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells
Abhishek Kumar Singh et al.
NEUROTOXICITY RESEARCH (2017)
Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders
Raul Delgado-Morales et al.
CLINICAL EPIGENETICS (2017)
From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)
Merce Pallas et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Animal Models of Alzheimer's Disease: Therapeutic Implications
Diana S. Woodruff-Pak
JOURNAL OF ALZHEIMERS DISEASE (2017)
Molecular Pathogenesis of Alzheimer's Disease: An Update
Alfredo Sanabria-Castro et al.
ANNALS OF NEUROSCIENCES (2017)
Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer's disease
Amandine Grimm et al.
BIOGERONTOLOGY (2016)
Oxidative Stress Is a Central Target for Physical Exercise Neuroprotection Against Pathological Brain Aging
Yoelvis Garcia-Mesa et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)
Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice
Christian Grinan-Ferre et al.
AGING-US (2016)
Ethical challenges in preclinical Alzheimer's disease observational studies and trials: Results of the Barcelona summit
Jose L. Molinuevo et al.
ALZHEIMERS & DEMENTIA (2016)
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria
Bruno Dubois et al.
ALZHEIMERS & DEMENTIA (2016)
Early onset of behavioral alterations in senescence-accelerated mouse prone 8 (SAMP8)
Shuichi Yanai et al.
BEHAVIOURAL BRAIN RESEARCH (2016)
SIRT6, oxidative stress, and aging
Chen-Yu Liao et al.
CELL RESEARCH (2016)
Schizophrenia risk variants affecting nnicroRNA function and site-specific regulation of NT5C2 by miR-206
Mads Engel Hauberg et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2016)
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence
Christian Grinan-Ferre et al.
EXPERIMENTAL GERONTOLOGY (2016)
MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions
Caterina Catalanotto et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Peripheral Administration of GSK-3β Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer's Disease
Susan A. Farr et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease
Niklas Mattsson et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)
A diet enriched with plant sterols prevents the memory impairment induced by cholesterol loss in senescence-accelerated mice
Azucena Perez-Canamas et al.
NEUROBIOLOGY OF AGING (2016)
Distribution of miRNA expression across human tissues
Nicole Ludwig et al.
NUCLEIC ACIDS RESEARCH (2016)
Ageing-Associated Oxidative Stress and Inflammation Are Alleviated by Products from Grapes
K. S. Petersen et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons
Ernest Palomer et al.
CELL REPORTS (2016)
Diagnostic value of microRNA for Alzheimer's Disease: A Systematic Review and Meta-Analysis
Yong-Bo Hu et al.
FRONTIERS IN AGING NEUROSCIENCE (2016)
Environmental Enrichment Modified Epigenetic Mechanisms in SAMP8 Mouse Hippocampus by Reducing Oxidative Stress and Inflammaging and Achieving Neuroprotection
Christian Grinan-Ferre et al.
FRONTIERS IN AGING NEUROSCIENCE (2016)
Current Research Therapeutic Strategies for Alzheimer's Disease Treatment
Jaume Folch et al.
NEURAL PLASTICITY (2016)
Aging and Neurodegeneration: A Tangle of Models and Mechanisms
Sasanka Chakrabarti et al.
AGING AND DISEASE (2016)
The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review
Ke-xin Wen et al.
PLOS ONE (2016)
ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model
Elizabeth S. Chan et al.
SCIENTIFIC REPORTS (2016)
Regulation of the p19Arf/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence-prone SAMP8 mice
Raul Soriano-Canton et al.
AGING CELL (2015)
In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes
Silvia Garcia-Matas et al.
AGING CELL (2015)
A comprehensive multiomics approach toward understanding the relationship between aging and dementia
Antonio Currais et al.
AGING-US (2015)
DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks
Christina A. Castellani et al.
BMC MEDICAL GENOMICS (2015)
Epigenetics of Aging
Marta I. Sierra et al.
CURRENT GENOMICS (2015)
DNA methylation is necessary for erythropoietin to improve spatial learning and memory in SAMP8 mice
Nengwei Yu et al.
EXPERIMENTAL GERONTOLOGY (2015)
MicroRNAs in cardiovascular disease: an introduction for clinicians
Simon P. R. Romaine et al.
HEART (2015)
Neuroinflammation in Alzheimer's disease
Michael T. Heneka et al.
LANCET NEUROLOGY (2015)
General hallmarks of microRNAs in brain evolution and development
Wei Chen et al.
RNA BIOLOGY (2015)
Early attenuation of long-term potentiation in senescence-accelerated mouse prone 8
Sakiko Taniguchi et al.
EXPERIMENTAL BRAIN RESEARCH (2015)
Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits
Guilian Xu et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Histone Deacetylase Inhibitor, Trichostatin A, Improves Learning and Memory in High-Fat Diet-Induced Cognitive Deficits in Mice
Sorabh Sharma et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2015)
Insufficient Resolution Response in the Hippocampus of a Senescence-Accelerated Mouse Model-SAMP8
Xiuzhe Wang et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2015)
Biochemical Characterization of Sirtuin 6 in the Brain and Its Involvement in Oxidative Stress Response
Alessio Cardinale et al.
NEUROCHEMICAL RESEARCH (2015)
Sodium butyrate, a histone deacetylase Inhibitor, ameliorates SIRT2-induced memory impairment, reduction of cell proliferation, and neuroblast differentiation in the dentate gyrus
Dae Young Yoo et al.
NEUROLOGICAL RESEARCH (2015)
Antisense against Amyloid-β Protein Precursor Reverses Memory Deficits and Alters Gene Expression in Neurotropic and Insulin-Signaling Pathways in SAMP8 Mice
Harvey J. Armbrecht et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice
Gemma Manich et al.
AGE (2014)
The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model
Xiao-rui Cheng et al.
AGEING RESEARCH REVIEWS (2014)
Effects of Negative Stressors on DNA Methylation in the Brain: Implications for Mood and Anxiety Disorders
Benjamin Hing et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2014)
Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice
Nan Lin et al.
BEHAVIOURAL BRAIN RESEARCH (2014)
Lenti-GDNF Gene Therapy Protects Against Alzheimer's Disease-Like Neuropathology in 3xTg-AD Mice and MC65 Cells
Susana Revilla et al.
CNS NEUROSCIENCE & THERAPEUTICS (2014)
Rcor2 underexpression in senescent mice: a target for inflammaging?
Maria J. Alvarez-Lopez et al.
JOURNAL OF NEUROINFLAMMATION (2014)
Cilostazol Suppresses β-Amyloid Production by Activating A Disintegrin and Metalloproteinase 10 Via the Upregulation of SIRT1-Coupled Retinoic Acid Receptor-β
Hye Rin Lee et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2014)
Epigenetics of Aging and Aging-related Disease
Anne Brunet et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
Histone core modifications regulating nucleosome structure and dynamics
Peter Tessarz et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
The Evolution of Preclinical Alzheimer's Disease: Implications for Prevention Trials
Reisa Sperling et al.
NEURON (2014)
SIRT1 in Neurodevelopment and Brain Senescence
A. Zara Herskovits et al.
NEURON (2014)
Oxidative Stress in Alzheimer's Disease: Why Did Antioxidant Therapy Fail?
Torbjorn Persson et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)
The synaptic plasticity and memory hypothesis: encoding, storage and persistence
Tomonori Takeuchi et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells
Yun Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer's Disease
Jana Hroudova et al.
BIOMED RESEARCH INTERNATIONAL (2014)
Epigenetic contributions to cognitive aging: disentangling mindspan and lifespan
Amy M. Spiegel et al.
LEARNING & MEMORY (2014)
Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8
David Porquet et al.
AGE (2013)
Amyloid β-Peptide (1-42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression
D. Allan Butterfield et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
Depression-like behavior is dependent on age in male SAMP8 mice
D. Perez-Caceres et al.
BIOGERONTOLOGY (2013)
Long and Short Non-Coding RNAs as Regulators of Hematopoietic Differentiation
Franck Morceau et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
Alterations in local thyroid hormone signaling in the hippocampus of the SAMP8 mouse at younger ages: Association with delayed myelination and behavioral abnormalities
Erika Sawano et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2013)
Epigenetic Regulation of Autophagy by the Methyltransferase G9a
Amaia Artal-Martinez de Narvajas et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Epigenetic regulation of memory formation and maintenance
Iva B. Zovkic et al.
LEARNING & MEMORY (2013)
Regulation of nucleosome dynamics by histone modifications
Gabriel E. Zentner et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice
Guomin Li et al.
NEUROLOGICAL SCIENCES (2013)
Age-related alteration in cerebral blood flow and energy failure is correlated with cognitive impairment in the senescence-accelerated prone mouse strain 8 (SAMP8)
Xuezhu Zhang et al.
NEUROLOGICAL SCIENCES (2013)
Propranolol restores cognitive deficits and improves amyloid and Tau pathologies in a senescence-accelerated mouse model
Marta Dobarro et al.
NEUROPHARMACOLOGY (2013)
Assessment of social interaction and anxiety-like behavior in senescence-accelerated-prone and -resistant mice
Harry C. Meeker et al.
PHYSIOLOGY & BEHAVIOR (2013)
Increased Histone H3 Phosphorylation in Neurons in Specific Brain Structures after Induction of Status Epilepticus in Mice
Tetsuji Mori et al.
PLOS ONE (2013)
Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice
Hong-Mei Wang et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2013)
The involvement of microRNAs in neurodegenerative diseases
Simona Maciotta et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2013)
The role of sirtuins in Alzheimer's disease
Rakhee Lalla et al.
FRONTIERS IN AGING NEUROSCIENCE (2013)
Nodes and biological processes identified on the basis of network analysis in the brain of the senescence accelerated mice as an Alzheimer's disease animal model
Xiao-rui Cheng et al.
FRONTIERS IN AGING NEUROSCIENCE (2013)
Epigenetic Determinants of Healthy and Diseased Brain Aging and Cognition
Schahram Akbarian et al.
JAMA NEUROLOGY (2013)
The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease
John E. Morley et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)
Histone H3 phosphorylation - A versatile chromatin modification for different occasions
Anna Sawicka et al.
BIOCHIMIE (2012)
A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts
R. Faraonio et al.
CELL DEATH AND DIFFERENTIATION (2012)
Applying Epigenetics to Alzheimer's Disease via the Latent Early-life Associated Regulation (LEARn) Model
Bryan Maloney et al.
CURRENT ALZHEIMER RESEARCH (2012)
The SAMP8 Mouse: A Model to Develop Therapeutic Interventions for Alzheimers Disease
John E. Morley et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
Gene promoter methylation is associated with lung function in the elderly The normative aging study
Johanna Lepeule et al.
EPIGENETICS (2012)
Histone phosphorylation A chromatin modification involved in diverse nuclear events
Dorine Rossetto et al.
EPIGENETICS (2012)
Oxidative Stress Mediated-Alterations of the MicroRNA Expression Profile in Mouse Hippocampal Neurons
Shunjiang Xu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
MicroRNAs and their roles in aging
Thalyana Smith-Vikos et al.
JOURNAL OF CELL SCIENCE (2012)
HDAC1 Regulates Fear Extinction in Mice
Sanaz Bahari-Javan et al.
JOURNAL OF NEUROSCIENCE (2012)
Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol
Rosa Cristofol et al.
JOURNAL OF PINEAL RESEARCH (2012)
Epigenetic mechanisms in neurological disease
Mira Jakovcevski et al.
NATURE MEDICINE (2012)
Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
Ana M. M. Oliveira et al.
NATURE NEUROSCIENCE (2012)
Histone methylation: a dynamic mark in health, disease and inheritance
Eric L. Greer et al.
NATURE REVIEWS GENETICS (2012)
Learning capabilities and CA1-prefrontal synaptic plasticity in a mice model of accelerated senescence
Juan Carlos Lopez-Ramos et al.
NEUROBIOLOGY OF AGING (2012)
Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model
Lourdes Orejana et al.
NEUROBIOLOGY OF AGING (2012)
MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice
Wei Liu et al.
NEUROBIOLOGY OF AGING (2012)
Novel MicroRNAs Differentially Expressed during Aging in the Mouse Brain
Sachi Inukai et al.
PLOS ONE (2012)
Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders
Zacharoula Konsoula et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2012)
Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors
Genevieve P. Delcuve et al.
CLINICAL EPIGENETICS (2012)
Epigenetic Control of Aging
Ursula Munoz-Najar et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxylcytosine
Martin Muenzel et al.
CHEMISTRY-A EUROPEAN JOURNAL (2011)
Chromatin structure as a mediator of aging
Jason Feser et al.
FEBS LETTERS (2011)
DNA Methylation and Demethylation in Mammals
Zhao-xia Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Epigenetic Mechanisms in Inflammation
D. Bayarsaihan
JOURNAL OF DENTAL RESEARCH (2011)
HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation
Susan C. McQuown et al.
JOURNAL OF NEUROSCIENCE (2011)
Spirulina Prevents Memory Dysfunction, Reduces Oxidative Stress Damage and Augments Antioxidant Activity in Senescence-Accelerated Mice
Juen-Haur Hwang et al.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2011)
HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner
Jakob Haettig et al.
LEARNING & MEMORY (2011)
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
Tian-Peng Gu et al.
NATURE (2011)
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
Gabriella Ficz et al.
NATURE (2011)
Neuronal activity modifies the DNA methylation landscape in the adult brain
Junjie U. Guo et al.
NATURE NEUROSCIENCE (2011)
Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency
Andrea Fuso et al.
NEUROBIOLOGY OF AGING (2011)
Epigenetic mechanisms in Alzheimer's disease
Diego Mastroeni et al.
NEUROBIOLOGY OF AGING (2011)
Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity
Stephen J. Haggarty et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2011)
ER Stress and Its Functional Link to Mitochondria: Role in Cell Survival and Death
Jyoti D. Malhotra et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)
Epigenetic Regulation of Learning and Memory by Drosophila EHMT/G9a
Jamie M. Kramer et al.
PLOS BIOLOGY (2011)
Disease progression meta-analysis model in Alzheimer's disease
Kaori Ito et al.
ALZHEIMERS & DEMENTIA (2010)
Mammalian Sirtuins: Biological Insights and Disease Relevance
Marcia C. Haigis et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
MicroRNAs: Synthesis, mechanism, function, and recent clinical trials
Fazli Wahid et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2010)
Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8
Chun Mei Wang et al.
BIOGERONTOLOGY (2010)
Neuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8)
M. Tajes et al.
EXPERIMENTAL GERONTOLOGY (2010)
Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8)
Sara Cuesta et al.
EXPERIMENTAL GERONTOLOGY (2010)
In Vitro and In Vivo Activation of Astrocytes by Amyloid-beta is Potentiated by Pro-Oxidant Agents
Silvia Garcia-Matas et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
A Physiological Role for Amyloid-beta Protein: Enhancement of Learning and Memory
John E. Morley et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Epigenetic alterations in aging
Susana Gonzalo
JOURNAL OF APPLIED PHYSIOLOGY (2010)
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Clifford R. Jack et al.
LANCET NEUROLOGY (2010)
Cortical DNA methylation maintains remote memory
Courtney A. Miller et al.
NATURE NEUROSCIENCE (2010)
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
Quincey LaPlant et al.
NATURE NEUROSCIENCE (2010)
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
Sang-Won Min et al.
NEURON (2010)
Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
Daniel Globisch et al.
PLOS ONE (2010)
Conservation and divergence of methylation patterning in plants and animals
Suhua Feng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Long noncoding RNAs: functional surprises from the RNA world
Jeremy E. Wilusz et al.
GENES & DEVELOPMENT (2009)
Reexamining Alzheimer's Disease: Evidence for a Protective Role for Amyloid-beta Protein Precursor and Amyloid-beta
Rudy J. Castellani et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
Increase in Presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing
Vijaya B. Kumar et al.
JOURNAL OF EXPERIMENTAL BIOLOGY (2009)
Proteomic study of neuron and astrocyte cultures from senescence-accelerated mouse SAMP8 reveals degenerative changes
Cristina Diez-Vives et al.
JOURNAL OF NEUROCHEMISTRY (2009)
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development
Andrew S. Yoo et al.
NATURE (2009)
HDAC2 negatively regulates memory formation and synaptic plasticity
Ji-Song Guan et al.
NATURE (2009)
Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar et al.
NATURE REVIEWS GENETICS (2009)
Autophagy upregulation and loss of NF-κB in oxidative stress-related immunodeficient SAMP8 mice
Beatriz Caballero et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2009)
Senescence-Accelerated Mouse (SAM) with Special References to Neurodegeneration Models, SAMP8 and SAMP10 Mice
Toshio Takeda
NEUROCHEMICAL RESEARCH (2009)
LONG-TERM GREEN TEA CATECHIN ADMINISTRATION PREVENTS SPATIAL LEARNING AND MEMORY IMPAIRMENT IN SENESCENCE-ACCELERATED MOUSE PRONE-8 MICE BY DECREASING Aβ1-42 OLIGOMERS AND UPREGULATING SYNAPTIC PLASTICITY-RELATED PROTEINS IN THE HIPPOCAMPUS
Q. Li et al.
NEUROSCIENCE (2009)
Age-related spatial cognitive impairment is correlated with a decrease in ChAT in the cerebral cortex, hippocampus and forebrain of SAMP8 mice
Feng Wang et al.
NEUROSCIENCE LETTERS (2009)
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani et al.
SCIENCE (2009)
Dysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacity
Silvia Garcia-Matas et al.
AGING CELL (2008)
Role of microRNAs in diabetes
Xiaoqing Tang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2008)
The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans
Ryusuke Niwa et al.
DEVELOPMENTAL BIOLOGY (2008)
Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice
Maria I. Rodriguez et al.
EXPERIMENTAL GERONTOLOGY (2008)
Experimental validation of miRNA targets
Donald E. Kuhn et al.
METHODS (2008)
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
Sebastien S. Hebert et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Histone deacetylase inhibitors: molecular mechanisms of action
W. S. Xu et al.
ONCOGENE (2007)
Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8
Javier Gutierrez-Cuesta et al.
JOURNAL OF PINEAL RESEARCH (2007)
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD
Carol A. Colton et al.
JOURNAL OF NEUROINFLAMMATION (2006)
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease
Susanne Hauptmann et al.
EXPERIMENTAL GERONTOLOGY (2006)
Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus
Jonathan M. Levenson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8
FX Sureda et al.
EXPERIMENTAL GERONTOLOGY (2006)
Elevated oxidative stress in the brain of senescence-accelerated mice at 5 months of age
O Alvarez-García et al.
BIOGERONTOLOGY (2006)
Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM)
AM Canudas et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
Reduction of NRI and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease
N Amada et al.
NEUROREPORT (2005)
MicroRNA function in animal development
E Wienholds et al.
FEBS LETTERS (2005)
The senescence-accelerated prone mouse (SAMP8): A model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease
DA Butterfield et al.
EXPERIMENTAL GERONTOLOGY (2005)
The genetic epidemidogy of neurodegenerative disease
L Bertram et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Principles of MicroRNA-target recognition
J Brennecke et al.
PLOS BIOLOGY (2005)
Biochemistry and biology of mammalian DNA methyltransferases
A Hermann et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2004)
Regulation of histone deacetylase activities
N Sengupta et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2004)
Antisense directed at the Aβ region of APP decreases brain oxidative markers in aged senescence accelerated mice
HF Poon et al.
BRAIN RESEARCH (2004)
Brain lipid hydroperoxide level increases in senescence-accelerated mice at an early age
F Yasui et al.
NEUROSCIENCE LETTERS (2003)
Histone deacetylases (HDACs): characterization of the classical HDAC family
AJM De Ruijter et al.
BIOCHEMICAL JOURNAL (2003)
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
R Jaenisch et al.
NATURE GENETICS (2003)
Hepatic mitochondrial dysfunction in senescence-accelerated mice: correction by long-term, orally administered physiological levels of melatonin
Y Okatani et al.
JOURNAL OF PINEAL RESEARCH (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Melatonin reduces oxidative damage of neural lipids and proteins in senescence-accelerated mouse
Y Okatani et al.
NEUROBIOLOGY OF AGING (2002)
Identification of tissue-specific microRNAs from mouse
M Lagos-Quintana et al.
CURRENT BIOLOGY (2002)
A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes
LZ Strichman-Almashanu et al.
GENOME RESEARCH (2002)
Passive avoidance and complex maze learning in the senescence accelerated mouse (SAM): Age and strain comparisons of SAM P8 and R1
EL Spangler et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2002)
The significance of environmental factors in the etiology of Alzheimer's disease
William B. Grant et al.
JOURNAL OF ALZHEIMERS DISEASE (2002)
DNA methylation patterns and epigenetic memory
A Bird
GENES & DEVELOPMENT (2002)
EBP2 is a member of the yeast RRB regulon, a transcriptionally coregulated set of genes that are required for ribosome and rRNA biosynthesis
C Wade et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Changes in expressions of proinflammatory cytokines IL-1β, TNF-α and IL-6 in the brain of senescence accelerated mouse (SAM) P8
KK Tha et al.
BRAIN RESEARCH (2000)
β-Amyloid precursor polypeptide in SAMP8 mice affects learning and memory
JE Morley et al.
PEPTIDES (2000)
Signaling to chromatin through histone modifications
P Cheung et al.
CELL (2000)
The DNA methyltransferases of mammals
TH Bestor
HUMAN MOLECULAR GENETICS (2000)
分享论文
