期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 62, 期 3, 页码 1113-1123出版社
IOS PRESS
DOI: 10.3233/JAD-170584
关键词
Biomarkers; cerebrospinal fluid; frontotemporal lobar degeneration; neuroimaging; transcranial magnetic stimulation
Frontotemporal dementia (FTD) is a heterogeneous clinical, genetic, and neuropathological disorder. Clinical diagnosis and prediction of neuropathological substrates are hampered by heterogeneous pictures. Diagnostic markers are key in clinical trials to differentiate FTD from other neurodegenerative dementias. In the same view, identifying the neuropathological hallmarks of the disease is key in light of future disease-modifying treatments. The aim of the present review is to unravel the progress in biomarker discovery, discussing the potential applications of available biological, imaging, and neurophysiological markers.
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