期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 64, 期 -, 页码 S23-S31出版社
IOS PRESS
DOI: 10.3233/JAD-179924
关键词
Alzheimer's disease; biomarkers; brain imaging; database analysis; diagnosis; human volunteer cohorts; precision medicine; translational research; treatment
资金
- Canadian Institutes for Health Research
- Weston Brain Institute
Cautious optimism is appropriate for a near future (five years) time frame for a number of drugs acting on the different pathophysiological components of Alzheimer's disease (amyloid deposition, tau hyperphosphorylation, neuroinflammation, vascular changes, to name the most important known so far). Since the relative weight of these components will be different between individuals and will even change over time for each individual, a 'one drug fit for all' approach is no longer defensible. Precision medicine using biomarkers in the diagnosis and treatment of Alzheimer's disease is the new strategy.
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