期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 64, 期 -, 页码 S299-S312出版社
IOS PRESS
DOI: 10.3233/JAD-179909
关键词
Apolipoprotein E; chronic traumatic encephalopathy; immunomodulation; innate immunity; oligomer; prion; Toll-like receptor 9; unbiased proteomics
资金
- NIH [NS073502, AG008051]
There is growing genetic and proteomic data highlighting the complexity of Alzheimer's disease (AD) pathogenesis. Greater use of unbiased omics approaches is being increasingly recognized as essential for the future development of effective AD research, that need to better reflect the multiple distinct pathway abnormalities that can drive AD pathology. The track record of success in AD clinical trials thus far has been very poor. In part, this high failure rate has been related to the premature translation of highly successful results in animal models that mirror only limited aspects of AD pathology to humans. We highlight our recent efforts to increase use of human tissue to gain a better understanding of the AD pathogenesis subtype variety and to develop several distinct therapeutic approaches tailored to address this diversity. These therapeutic approaches include the blocking of the A beta/apoE interaction, stimulation of innate immunity, and the simultaneous blocking of A beta/tau oligomer toxicity. We believe that future successful therapeutic approaches will need to be combined to better reflect the complexity of the abnormal pathways triggered in AD pathogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据