Potential interplay between NFκB and PPARγ in human dermal microvascular endothelial cells cultured in low magnesium

Dermal microvascular endothelial cells contribute to cutaneous inflammation by secreting proinflammatory cytokines and chemokines. We show here that low extracellular magnesium stimulates the secretion of interleukin 8 and monocyte chemoattractant protein-1 in dermal microvascular endothelial cells. This secretory pattern might result from interplay between NF kappa B, the master regulator of inflammation, and PPAR gamma, a transcription factor that has emerged as an inhibitor of inflammation. Indeed, both NF kappa B and PPAR gamma are activated in dermal microvascular endothelial cells cultured in low magnesium-containing medium. In conclusion, we hypothesize that PPAR gamma and NF kappa B might contribute to the response of these cells to low Mg.