期刊
CLINICAL PSYCHOLOGICAL SCIENCE
卷 2, 期 6, 页码 740-747出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/2167702614527948
关键词
RDoC; oxytocin; social anxiety disorder; social rejection; individual differences
资金
- Boston University Department of Psychology Clara Mayo Memorial Fellowship
- John Leopold Weil and Geraldine Rickard Weil Memorial Charitable Foundation Dissertation Award
- National Institutes of Health/National Center for Complementary and Alternative Medicine Grant [R01AT007257]
- German Research Foundation (DFG)
- European Neuroscience Network NEUREX
Whereas the Diagnostic and Statistical Manual of Mental Disorders (DSM) categorizes individuals with similar self-reported symptoms, the research domain criteria offers a new approach for classifying mental disorders on the basis of dimensions of observable behaviors and neurobiological measures. The objective of this proof-of-concept study was to adopt this approach by distinguishing individuals on the basis of disorder-related personality traits during an experimental manipulation that targeted a disorder-related biological mechanism. In a double-blind, placebo-controlled study design, we examined whether attachment style moderated the effect of oxytocin administration on social behaviors and cognitions during a social-exclusion test in individuals with social anxiety disorder. Among participants who received oxytocin, as opposed to a placebo, only individuals with low attachment avoidance displayed more social affiliation and cooperation, and only those with high attachment avoidance showed faster detection of disgust and neutral faces. Thus, attachment style moderated oxytocin's effects among individuals who shared the same DSM diagnosis. We conclude that neurobiological tests can inform new classification strategies by adopting a research domain criteria framework.
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