期刊
EMERGING INFECTIOUS DISEASES
卷 20, 期 11, 页码 1848-1856出版社
CENTERS DISEASE CONTROL
DOI: 10.3201/eid2011.131215
关键词
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资金
- Wellcome Trust
- Fondo de Investigaciones Sanitarias de la Seguridad Social [PI11/00763]
- Plan Nacional de I + D + I of the Ministerio de Ciencia e Innovacion of Spain [BIO2011-25343]
- Centros de Investigacion Biomedica en Red (CIBER) de Enfermedades Respiratorias, an initiative of the Instituto de Salud Carlos III, Madrid, Spain [CIBERES-CB06/06/0037]
- Pfizer
Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC >= 16 mu g/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-5T63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invaeive disease in Spain.
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