期刊
GENETICS AND MOLECULAR RESEARCH
卷 14, 期 4, 页码 17426-17431出版社
FUNPEC-EDITORA
DOI: 10.4238/2015.December.21.12
关键词
Breast cancer; G10398A mutation; Haplogroup
资金
- Zhejiang Provincial Natural Science Foundation [LQ13H280002]
- Henan Basic and Frontier Technology Tesearch Projects [142300410388, 132300410048]
- Wenling Foundation of Science and Technology [2011WLCB0109, 2014C311051, 2015C312055]
- Public Project of Science and Technology of Wenzhou City [Y20140739, Y20150094]
- Project of Medical Technology of Zhejiang Province [2015KYB234]
- Shaoxing Science and Technology Project [2012B70058, 2013B70066]
Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and molecular datasets from case-control studies to determine the association between the G10398A mutation and breast cancer. We further used the Phylotree to determine the haplogroups of this mutation. The frequencies of this mutation in 500 unrelated healthy controls were also screened. We found that this mutation is very common in the human population, and may be a polymorph.
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