期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 141, 期 1, 页码 11-19出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2017.11.005
关键词
Food allergy; sensitization; tolerance; desensitization; sustained unresponsiveness; remission; allergen immunotherapy; microbiota
资金
- National Institute of Allergy and Infectious Diseases [AI-44236]
- NIH AITC Review Panel
- Allertein
- American Society for Microbiology
- Elsevier
- FARE
- World Allergy Organization
- Adept Field Solutions
- Aimmune Therapeutics, Inc
- Astellas Pharma Global Development, Inc
- Biomerica, Inc
- Evelo Biosciences, Inc/Epiva Biosciences, Inc
- First Manhattan Co
- Genentech
- GLG Research, Inc
- Insys Therapeutics
- Intrommune Therapeutics
- PPD Development, LP
- Regeneron Pharmceuticals, Inc
- Sanofi US Services
- SRA International
- Stallergenes
- UKKO, Inc
- Valeant Pharmaceuticals North America, LLC
- National Institutes of Health
- Wallace Research Foundation
- National Institutes of Allergy and Infectious Diseases [NO1-AI-15416, UM1AI109565]
- Food Allergy Research and Education (FARE)
- MRC & Asthma UK Centre
- UK Department of Health through the National Institute for Health Research
- National Peanut Board
- Osem
- Actellion
- European Union project Medall
- Allergopharma
- Swiss National Science Foundation
- Christine Kuhne Center for Allergy Research and Education
- European Union project Predicta
Although oral tolerance is the normal physiologic response to ingested antigens, a breakdown in this process appears to have occurred in the past 2 decades, leading to an increasing prevalence of sensitization to food allergens. Over the past decade, basic research has intensified in an attempt to better understand the mechanisms leading to sensitization and disease versus desensitization and short- and long-term tolerance. In this review we assess various factors that can influence tissue and immune responses to food antigens, the current understanding of immune tolerance development, the role of the gastrointestinal microbiota, and current knowledge regarding immunologic mechanisms involved in desensitization and sustained unresponsiveness, although perhaps the latter is more appropriately termed remission.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据