期刊
FEMS MICROBIOLOGY REVIEWS
卷 38, 期 6, 页码 1172-1201出版社
OXFORD UNIV PRESS
DOI: 10.1111/1574-6976.12083
关键词
nutrient depletion; translational stalling; toxin-antitoxin modules; mRNA truncation; stationary phase; antibiotic stress
类别
资金
- Deutsche Forschungsgemeinschaft [FOR1805, WI3285/4-1, Exc114-2]
- National Institutes of Health [NIHR01GM095737]
- EMBO Young Investigator Program
- AXA Research Fund Postdoctoral Fellowship
Throughout their life, bacteria need to sense and respond to environmental stress. Thus, such stress responses can require dramatic cellular reprogramming, both at the transcriptional as well as the translational level. This review focuses on the protein factors that interact with the bacterial translational apparatus to respond to and cope with different types of environmental stress. For example, the stringent factor RelA interacts with the ribosome to generate ppGpp under nutrient deprivation, whereas a variety of factors have been identified that bind to the ribosome under unfavorable growth conditions to shut-down (RelE, pY, RMF, HPF and EttA) or re-program (MazF, EF4 and BipA) translation. Additional factors have been identified that rescue ribosomes stalled due to stress-induced mRNA truncation (tmRNA, ArfA, ArfB), translation of unfavorable protein sequences (EF-P), heat shock-induced subunit dissociation (Hsp15), or antibiotic inhibition (TetM, FusB). Understanding the mechanism of how the bacterial cell responds to stress will not only provide fundamental insight into translation regulation, but will also be an important step to identifying new targets for the development of novel antimicrobial agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据