期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 66, 期 30, 页码 7948-7957出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b02266
关键词
etc-pyrrolidinone; (-)-epicatechin-O-gallate (ECG); Camellia sinensis; (-)-catechin-O-gallate (CG); human umbilical vein endothelia cells (HUVECs)
资金
- The Open Fund of State Key Laboratory of Tea Plant Biology and Utilization [SKLTOF20160108]
- National Modern Agriculture Technology System Grant [CARS-23]
Chinese Xi-Gui tea is one ancient cultivated variety of Camellia sinensis var. assamica. At present, it is used for producing expensive and elite tea in China. Five new flavoalkaloids, (-)-6-(5 ''' S)-N-ethyl-2-pyrrolidinone-epicatechin-3-O-gallate (ester-type catechins pyrrolidinone E, etc-pyrrolidinone E, 1), (-)-6-(5 ''' R)-N-ethyl-2-pyrrolidinone-epicatechin-3-O-gallate (etc-pyrrolidinone F, 2) (-)-8-(5 ''' S)-N-ethyl-2-pyrrolidinone-epicatechin-3-O-gallate (etc-pyrrolidinone G, 3a), (-)-8(5 ''' S)-N-ethyl-2-pyrrolidinone-catechin-3-O-gallate (etc-pyrrolidinone I, 4a), (-)-8-(5 ''' R)-N-ethyl-2-pyrrolidinone-catechin-3-O-gallate (etc-pyrrolidinone J, 4b), and one new naturally occurring natural product (-)-8-(5 ''' R)-N-ethyl-2-pyrrolidinoneepicatechin-3-O-gallate (etc-pyrrolidinone H, 3b) together with the known flavoalkaloids etc-pyrrolidinones A-D (5, 6, 7a, and 7b) were detected and isolated from Xi-Gui green tea. Their structures were identified by comprehensive NMR spectroscopic analyses. Absolute configurations of 1-3 were established by comparison of the CD analyses with epicatechin-3-O-gallate (ECG). Compounds 1-4 were evaluated for their protection against high glucose induced cell senescence on human umbilical vein endothelia cells (HUVECs) and showed significant protection effects (p < 0.01) at both 1.0 and 10 mu M. A discussion on the possible evolution of tea plants divergent from related food plants on the basis of phytochemical view is also provided.
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