期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 66, 期 9, 页码 2151-2158出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b00535
关键词
A-type procyanidin analogues; procyanidin A-2; flavylium salts; antimicrobial activity; antibiofilm activity; resistant bacteria
资金
- University of Jaen
- Andalusian Government (Junta de Andalucia)
- Centro de Instrumentacion Cientifico-Tecnica of the University of Jaen
Natural A-type procyanidins have shown very interesting biological activities, such as their proven antiadherence properties against pathogenic bacteria. In order to find the structural features responsible for their activities, we describe herein the design and synthesis of six A-type procyanidin analogues and the evaluation of their antimicrobial and antibiofilm properties against 12 resistant bacteria, both Gram positive and Gram negative, isolated from organic foods. The natural A-type procyanidin A-2, which had known antiadherence activity, was also tested as a reference compound for the comparative studies. Within the series, analogue 4, which had a NO2 group on ring A, showed the highest antimicrobial activity (MIC of 10 mu g/mL) and was one of the best molecules at preventing biofilm formation (up to 40% decreases at 100 mu g/mL) and disrupting preformed biofilms (up to 40% reductions at 0.1 mu g/mL). Structure-activity relationships are also analyzed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据