期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 66, 期 3, 页码 621-629出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b04921
关键词
yeast beta-glucan; inflammation; obesity; adipose tissue; gut microbiota
资金
- National Key R&D Program of China [2016YFD0400202]
- National Natural Science Foundation of China [21574102, 21274114, 21334005]
- New Century Excellent Talents Program of Education Ministry [NCET-13-0442]
Inflammation in visceral adipose tissues (VATs) contributes to the pathology of diabetes. This study focused on the inflammatory regulation in VATs by a yeast beta-1,3-glucan (BYG) orally administered to ob/ob mice. BYG decreased pro-inflammatory modulators of TNF-alpha, IL-6, IL-1 beta, CCL2, and SAA3, and increased anti-inflammatory factors of Azgp1 (2.53 +/- 0.02-fold change) at protein and/or mRNA levels (p < 0.05). Remarkably, BYG decreased the degree of adipose tissue macrophages (ATMs) infiltration to 82.5 +/- 8.3%, especially the newly recruited ATMs. Interestingly, BYG increased the protective Th2 cell regulator GATA3 (7.72 +/- 0.04-fold change) and decreased immunosuppressors IL-10 and IL-1ra, suggesting that BYG elicited inflammation inhibition via stimulating immune responses. Additionally, BYG increased the gut microbiota proportion of Akkermansia from 0.07% to 4.85% and improved the microenvironment of VATs through decreasing fibrosis and angiogenesis. These findings suggest that BYG has anti-inflammatory effect in diabetic mice, which can be used as a food component and/or therapeutic agent for diabetes.
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