期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 66, 期 17, 页码 4384-4393出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b00710
关键词
tea polysaccharides (TPS); colitis-associated cancer (CAC); interleukin-6 (IL-6); signal transducer and activator of transcription-3 (STAT3)
资金
- National Key Technology R& D Program of China
- Key Program of National Natural Science Foundation of China
- Program for New Century Excellent Talents in University
- Research Project of State Key Laboratory of Food Science and Technology
- Excellent Youth Foundation of National Natural Science Foundation of China [31422042]
- Key Program of National Natural Science Foundation of China [31130041]
- National Natural Science Foundation of China [31560438]
- Natural Science Foundation of Jiangxi Province, China [20161BAB214163]
The interleukin-6 (IL-6)/signal transducer and activator of transcription (STAT)-3 signaling pathway regulates proliferation and survival of intestinal epithelial cells and has profound impact on the tumorigenesis of colitis-associated cancer (CAC). Tea polysaccharides (TPS) are the major nutraceutical component isolated from tea-leaves and are known to possess antioxidant, anti-inflammatory, and antitumor bioactivities. Here, we investigated the antitumor activities of TPS on CAC using the azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model and IL-6-induced colorectal cancer cell line (CT26) and determined whether TPS exerted its antitumor effects through the IL-6/STAT3 pathway. Results demonstrated that TPS significantly decreased the tumor incidence, tumor size, and markedly inhibited the infiltration of pro-inflammatory cells and the secretion of pro-inflammatory cytokines via balancing cellular microenvironment. Furthermore, we found that TPS suppressed the activation of STAT3 and transcriptionally regulated the expressions of downstream genes including MMP2, cyclin Dl, survivin, and VEGF both in vivo and in vitro. Thus, it was concluded that TPS attenuated the progress of CAC via suppressing IL-6/STAT3 pathway and downstream genes' expressions, which indicated that TPS may be a hopeful antitumor agent for the prevention and treatment of colon cancer.
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