期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 66, 期 16, 页码 4106-4117出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b00385
关键词
aquaporins; ATPase activities; bacterial cellulose; diphenoxylate-induced constipation; intestinal neurotransmitters
资金
- International Scientific and Technological Cooperation and Exchange Program [2016KW068]
- Postdoctoral Program of China [1202040108]
- National Natural Science Foundation of China [C31671823, C31701662]
This study was to probe the effects of bacterial cellulose (BC) on diphenoxylate-induced constipation in rats. Administration with BC at 500 mg/kg of body weight in diphenoxylate-induced constipation rats distinctly improved the carmine propulsion rate (83.5 +/- 5.2%), shortened the defecating time of the first red feces (249.0 +/- 23.3 min), and increased the weight of carmine red feces within 5 h (2.7 +/- 1.3 g). The levels of aquaporins (AQP-2, AQP-3, and AQP-4) and inhibitory neurotransmitters (nitric oxide, nitric oxide synthetase, vasoactive intestinal peptide, and arginine vasopressin) in the BC-treated groups reduced by 31.9-40.0% (p < 0.01) and 21.1-67.7% (p < 0.01) compared to those in the constipation group, respectively. However, the secretion of excitability neurotransmitters (substance P and motilin) in the BC-treated groups was increased by 20.0-39.9% (p < 0.01). The activities of ATPases in the colon of constipation rats were significantly weakened by BC administration (p < 0.01). Histological morphology of the colon showed that BC supplementation could effectively increase the length of villus cells and the thickness of colonic mucosa and muscle (p < 0.01). Moreover, BC supplementation could protect colonic smooth muscle cells against apoptosis. All of the findings suggest that BC supplementation effectively relieves constipation in rats and BC would be used as a great promising dietary fiber for alleviating constipation.
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