Depression and anxiety symptoms are associated with prooxidant-antioxidant balance: A population-based study

Background: Depression and anxiety are significantly associated with systemic inflammation. Moreover, oxidative stress resulting from a disturbance in the prooxidant-antioxidant balance is linked to inflammation-related conditions. Therefore, depression/anxiety symptoms may also be associated with oxidative stress. Objective: To examine the association between depression/anxiety symptoms and serum prooxidant-antioxidant balance (PAB) in adults who participated in a large population-based, cross-sectional study. Methods: Serum PAB values were measured in 7516 participants (62% females and 38% males) aged 35-65 years, enrolled in a population-based cohort study. beck depression and anxiety inventories were used to evaluate symptoms of depression and anxiety. Multinomial logistic regression was used to examine the effect of confounders on the status of serum PAB change. Results: Among men, serum PAB values were increased incrementally from 1.55 +/- 0.47 to 1.59 +/- 0.47, 1.69 +/- 0.38, and 1.68 +/- 0.38 in the no or minimal, mild, moderate and severe depression groups, respectively (P-trend< 0.001). Serum PAB values also increased significantly across these four corresponding groups among women [1.70 +/- 0.45, 1.73 +/- 0.44, 1.75 +/- 0.44, and 1.76 +/- 0.40, (P-trend=0.005)]. About anxiety, serum PAB values increased significantly across the four groups in men (P-trend=0.02) but not in women (P-trend=0.2). The adjusted odds ratios for serum PAB values among men with severe depression and anxiety symptoms were 1.75 and 1.27, respectively. Moreover, the adjusted odds ratios for serum PAB values among women with severe depression and anxiety symptoms were 1.40 and 1.17, respectively. Conclusion: Symptoms of depression and anxiety appear to be associated with higher degrees of oxidative stress, expressed by higher serum PAB values.