期刊
JORNAL DE PEDIATRIA
卷 95, 期 5, 页码 567-574出版社
SOC BRASIL PEDIATRIA
DOI: 10.1016/j.jped.2018.05.011
关键词
Adolescents; Oral contraceptives; Bone density; Osteocalcin; Bone remodeling; Prospective study
类别
资金
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [07/07731-0, 2011/05991-0, 2015/04040-2]
- UNESP
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [07/07731-0] Funding Source: FAPESP
Objective: The objective of this study was to evaluate the effects of two low-dose combined oral contraceptives on bone metabolism in adolescents for one year. Methods: This was a quasi-experimental study. The adolescents were divided into three groups: oral contraceptives 1 (n = 42) (20 mu g EE/150 mu g desogestrel), oral contraceptives 2 (n = 66) (30 mu g EE/3 mg drospirenone), and a control group (n= 70). Adolescents underwent anthropometric assessment and densitometry (dual-energy X-ray). Bone age and bone formation markers (osteocalcin and bone alkaline phosphatase) were evaluated. The oral contraceptives users were evaluated again after 12 months. Linear regression analysis was used to indirectly study the effect of each additional year of chronological age on anthropometric and densitometric variables as well as on bone markers in the control group. Results: At study entry, no significant differences were observed between the oral contraceptives 1, oral contraceptives 2, and controls in the analyzed variables. Linear regression analysis showed an increase in bone mineral density and bone mineral content for each additional There was a significant reduction in bone alkaline phosphatase levels; no significant difference was observed for osteocalcin in control individuals. Comparison of dual-energy X-ray variables at baseline and after one year showed no significant differences in the oral contraceptives 1 or oral contraceptives 2 groups. A significant reduction in bone alkaline phosphatase and osteocalcin levels was observed in both the oral contraceptives 1 and oral contraceptives 2 groups. Conclusion: Adolescent women gain peak bone mass during this phase of life. Two low-dose combined oral hormonal contraceptives were associated with lower bone gain and lower bone formation markers than in untreated controls. (C) 2018 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据