期刊
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
卷 55, 期 10, 页码 6459-6466出版社
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.14-15177
关键词
in vivo; OCT; structure
资金
- National Institutes of Health (Bethesda, MD, USA) [R01-EY013178, R01-EY023966, R44-EY018986, P30-EY008098, T32-EY017271]
- Eye and Ear Foundation (Pittsburgh, PA, USA)
- Research to Prevent Blindness (New York, NY, USA)
PURPOSE. To characterize the in vivo three-dimensional (3D) lamina cribrosa (LC) micro-architecture of healthy eyes using adaptive optics spectral-domain optical coherence tomography (AO-SDOCT). METHODS. A multimodal retinal imaging system with a light source centered at 1050 nm and AO confocal scanning laser ophthalmoscopy was used in this study. One randomly selected eye from 18 healthy subjects was scanned in a 6 degrees x 6 degrees window centered on the LC. Subjects also underwent scanning with Cirrus HD-OCT. Lamina cribrosa microarchitecture was semiautomatically segmented and quantified for connective tissue volume fraction (CTVF), beam thickness, pore diameter, pore area, and pore aspect ratio. The LC was assessed in central and peripheral regions of equal areas and quadrants and with depth. A linear mixed effects model weighted by the fraction of visible LC was used to compare LC structure between regions. RESULTS. The nasal quadrant was excluded due to poor visualization. The central sector showed greater CTVF and thicker beams as compared to the periphery (P < 0.01). Both superior and inferior quadrants showed greater CTVF, pore diameter, and pore mean area than the temporal quadrant (P < 0.05). Depth analysis showed that the anterior and posterior aspects of the LC contained smaller pores with greater density and thinner beams as compared to the middle third (P < 0.05). The anterior third also showed a greater CTVF than the middle third (P < 0.05). CONCLUSIONS. In vivo analysis of healthy eyes using AO-SDOCT showed significant, albeit small, regional variation in LC microarchitecture by quadrant, radially, and with depth, which should be considered in further studies of the LC.
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