期刊
JAPANESE JOURNAL OF APPLIED PHYSICS
卷 57, 期 6, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.7567/JJAP.57.065103
关键词
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资金
- JST CREST Grant from Japan Science and Technology agency [JPMJCR15F4]
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) [16K13638]
Graphene FET (G-FET) biosensors have considerable potential due to the superior characteristics of graphene. Realizing this potential requires judicious choice of the linker molecule connecting the target-specific receptor molecule to the graphene surface, yet there are few reports comparing linker molecules for G-FET biosensors. In this study, tetrakis(4-carboxyphenyl) porphyrin (TCPP) was used as a linker for surface modification of a G-FET and the properties of the device were compared to those of a G-FET device modified with the conventional linker 1-pyrenebutanoic acid succinimidyl ester (PBASE). TCPP modification resulted in a higher density of receptor immunoglobulin E (IgE) aptamer molecules on the G-FET. The detection limit of the target IgE was enhanced from 13nM for the PBASE-modified G-FET to 2.2nM for the TCPP-modified G-FET, suggesting that the TCPP linker is a powerful candidate for G-FET modification. (C) 2018 The Japan Society of Applied Physics
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