期刊
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
卷 32, 期 5, 页码 689-700出版社
IOS PRESS
DOI: 10.3233/RNN-140409
关键词
Vascular dementia (VaD); repetitive transcranial magnetic stimulation (rTMS); learning and memory; mammalian target of rapamycin (mTOR); eukaryotic translation initiation factor 4 (eIF-4E); Morris Water Maze; 2-vessel occlusion
资金
- National Natural Science Foundation of China [81101176, 61074131]
- Natural Science Foundation of Tianjin City of China [14JCYBJC25000]
- Key Project of Tianjin Health Care Professionals [12KG116]
Purpose: The present study clarified the effects of repetitive transcranial magnetic stimulation (rTMS) in rats with vascular dementia (VaD) and explored the underlying mechanisms. Methods: Two-vessel occlusion was used as a VaD model. Two weeks after carotid artery occlusion, high (5 Hz) or low (1 Hz) frequency rTMS were applied for 10 days. Spatial learning and memory abilities were tested with a Morris water maze. Hippocampal CA1 neurons were histologically examined. The expressions of mammalian target of rapamycin (mTOR) and eukaryotic initiation factor 4E (eIF-4E) in CA1 were detected by western blot, and immunohistochemistry. Results: Unlike unlesioned control animals, VaD rats had an impaired morphology of CA1 neurons and a reduced ability of spatial memory. rTMS significantly improved both, the morphology and the learning and memory abilities of VaD rats compared to untreated lesioned rats. Protein expressions of mTOR and eIF-4E in CA1 of VaD rats were lower than in control rats but rTMS significantly increased the expression compared to untreated VaD rats. Conclusions: rTMS promotes recovery of learning and memory abilities of VaD rats. Molecular analysis suggests that the beneficial effect of rTMS may be partly induced by upregulation of protein expressions of mTOR and eIF-4E in CA1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据