期刊
BMC DERMATOLOGY
卷 14, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1471-5945-14-18
关键词
Innate lymphoid cells; Atopic dermatitis; Psoriasis; IL-33; IL-25; TSLP; PGD2; KLRG1; E-cadherin
类别
资金
- MRC
- Barrie Trust
- NIHR Biomedical Research Centre Programme
- MRC [MC_UU_12010/5] Funding Source: UKRI
Innate lymphoid cells are an emerging family of effector cells that contribute to lymphoid organogenesis, metabolism, tissue remodelling and protection against infections. They maintain homeostatic immunity at barrier surfaces such as lung, skin and gut (Nature 464: 1367-1371, 2010, Nat Rev Immunol 13: 145-149, 2013). Several human and mouse studies suggest a role for innate lymphoid cells in inflammatory skin conditions including atopic eczema and psoriasis. Here we review the innate lymphoid cell family and discuss their function in the skin and during inflammation.
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