期刊
ISME JOURNAL
卷 12, 期 8, 页码 1964-1976出版社
SPRINGERNATURE
DOI: 10.1038/s41396-018-0151-8
关键词
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资金
- Spanish Ministry of Economy and Competitiveness [SAF 2012-31187, SAF2013-49788-EXP, SAF2015-65878-R, CTQ2014-55279-R, BIO2014-54494-R]
- Carlos III Institute of Health [PIE14/00045, AC15/00022]
- Generalitat Valenciana [PrometeoII/2014/065]
- FEDER
- Instituto de Salud Carlos III (Plan Estatal de IpDpi) [PI15/00345]
- Spanish AIDS Research Network [RD16/0025/0001]
- European Development Regional Fund A way to achieve Europe (ERDF)
- CONACYT-SECITI fellowship, Mexico
- Spanish Ministry of Science and Innovation (Contratos Juan Rodes) [ECC/1051/2013]
- Hospital Universitario Ramon y Cajal
- Hospital Clinico San Carlos
- Fomento de la Investigacion Sanitaria y Biomedica de la Comunidad Valenciana (FISABIO) [UGP-14-116]
HIV infection causes a disruption of gut-associated lymphoid tissue, driving a shift in the composition of gut microbiota. A deeper understanding of the metabolic changes and how they affect the interplay with the host is needed. Here, we assessed functional modifications of HIV-associated microbiota by combining metagenomic and metatranscriptomic analyses. The transcriptionally active microbiota was well-adapted to the inflamed environment, overexpressing pathways related to resistance to oxidative stress. Furthermore, gut inflammation was maintained by the Gram-negative nature of the HIV-associated microbiota and underexpression of anti-inflammatory processes, such as short chain fatty acid biosynthesis or indole production. We performed co-occurrence and metabolic network analyses that showed relevance in the microbiota structure of both taxonomic and metabolic HIV-associated biomarkers. The Bayesian network revealed the most determinant pathways for maintaining the structure stability of the bacterial community. In addition, we identified the taxa' s contribution to metabolic activities and their interactions with host health.
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