期刊
ISME JOURNAL
卷 12, 期 9, 页码 2292-2306出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41396-018-0204-z
关键词
-
资金
- Spanish Ministry of Economy and Competitiveness [BIO2015-68711-R]
- Research Council for the South-East Sweden [79001]
- Swedish Research Council [2016-01698]
- Swedish Heart and Lung Foundation [20140321]
- Medical Research Council of Southeast Sweden [FORSS-573471]
- Cancer and Allergy Foundation
- European Research Council (ERC) [639226]
- Swedish Research Council [2016-01698] Funding Source: Swedish Research Council
Information on how the oral microbiome develops during early childhood and how external factors influence this ecological process is scarce. We used high-throughput sequencing to characterize bacterial composition in saliva samples collected at 3, 6, 12, 24 months and 7 years of age in 90 longitudinally followed children, for whom clinical, dietary and health data were collected. Bacterial composition patterns changed through time, starting with early colonizers, including Streptococcus and Veillonella; other bacterial genera such as Neisseria settled after 1 or 2 years of age. Dental caries development was associated with diverging microbial composition through time. Streptococcus cristatus appeared to be associated with increased risk of developing tooth decay and its role as potential biomarker of the disease should be studied with species-specific probes. Infants born by C-section had initially skewed bacterial content compared with vaginally delivered infants, but this was recovered with age. Shorter breastfeeding habits and antibiotic treatment during the first 2 years of age were associated with a distinct bacterial composition at later age. The findings presented describe oral microbiota development as an ecological succession where altered colonization pattern during the first year of life may have long-term consequences for child's oral and systemic health.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据