期刊
ISME JOURNAL
卷 12, 期 7, 页码 1642-1657出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41396-018-0068-2
关键词
-
资金
- Spanish Ministry of Economy and Competitiveness [PI15/00143, PI12/01373, PI15/01934, SAF2015-65878-R, PI14/00228, SAF2015-65019-R]
- Instituto de Salud Carlos III [AC15/00022]
- Generalitat Valenciana [PrometeoII/2014/065]
- European Regional Development Fund (ERDF)
- Ramon y Cajal' program from the Ministerio de Educacion y Ciencia [RYC2013-13186]
- ERDF
- Miguel Servet tenure-track program from the Fondo de Investigacion Sanitaria (FIS) - ERDF [CPII16/00008, CP15/00028]
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects. Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism. This increase was associated with specific changes in gut microbiota related to succinate metabolism: a higher relative abundance of succinate-producing Prevotellaceae (P) and Veillonellaceae (V), and a lower relative abundance of succinate-consuming Odoribacteraceae (O) and Clostridaceae (C) in obese individuals, with the (P + V/O + C) ratio being a main determinant of plasma succinate. Weight loss intervention decreased (P + V/O + C) ratio coincident with the reduction in circulating succinate. In the spontaneous evolution after good dietary advice, alterations in circulating succinate levels were linked to specific metagenomic signatures associated with carbohydrate metabolism and energy production with independence of body weight change. Our data support the importance of microbe-microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据