期刊
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
卷 16, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12968-014-0094-9
关键词
DENSE; Cardiovascular magnetic resonance; Cardiac mechanics
资金
- National Institutes of Health (NIH) Director's Early Independence Award [DP5 OD-012132]
- National Institute of General Medical Science of the National Institutes of Health [8 P20 GM103527]
- University of Kentucky Cardiovascular Research Center
- National Center for Research Resources (NCRR) - Office of the Director, National Institutes of Health [UL1TR000117]
- NIH Roadmap for Medical Research
Background: Cardiovascular magnetic resonance using displacement encoding with stimulated echoes (DENSE) is capable of assessing advanced measures of cardiac mechanics such as strain and torsion. A potential hurdle to widespread clinical adoption of DENSE is the time required to manually segment the myocardium during post-processing of the images. To overcome this hurdle, we proposed a radical approach in which only three contours per image slice are required for post-processing (instead of the typical 30-40 contours per image slice). We hypothesized that peak left ventricular circumferential, longitudinal and radial strains and torsion could be accurately quantified using this simplified analysis. Methods and Results: We tested our hypothesis on a large multi-institutional dataset consisting of 541 DENSE image slices from 135 mice and 234 DENSE image slices from 62 humans. We compared measures of cardiac mechanics derived from the simplified post-processing to those derived from original post-processing utilizing the full set of 30-40 manually-defined contours per image slice. Accuracy was assessed with Bland-Altman limits of agreement and summarized with a modified coefficient of variation. The simplified technique showed high accuracy with all coefficients of variation less than 10% in humans and 6% in mice. The accuracy of the simplified technique was also superior to two previously published semi-automated analysis techniques for DENSE post-processing. Conclusions: Accurate measures of cardiac mechanics can be derived from DENSE cardiac magnetic resonance in both humans and mice using a simplified technique to reduce post-processing time by approximately 94%. These findings demonstrate that quantifying cardiac mechanics from DENSE data is simple enough to be integrated into the clinical workflow.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据