期刊
JOURNAL OF MEDICAL ULTRASOUND
卷 22, 期 4, 页码 183-193出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.1016/j.jmu.2014.11.001
关键词
blood-brain barrier; central nervous system disease; focused ultrasound; microbubbles
The blood-brain barrier is a specialized protective structure in the central nervous system, which is critical for maintaining brain homeostasis and low permeability to control the passage of molecules from the circulation into the brain parenchyma and the efflux from the brain. However, the blood-brain barrier also hinders the transportation of therapeutic agents and contrast agents from the blood into brain tissue, lowering treatment efficiency. Recently, focused ultrasound sonication with microbubbles has been proved to transiently open the bloodebrain barrier, allowing the penetration of administered agents or drugs into the brain. In this article, we review the current state of this drug delivery technique, its application in preclinical brain disease models, and treatment planning for this novel technique. (C) 2014, Elsevier Taiwan LLC and the Chinese Taipei Society of Ultrasound in Medicine. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据