期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 546, 期 1-2, 页码 215-225出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2018.05.045
关键词
PAMAM dendrimer; Drug delivery; Gene therapy; Multidrug resistance; Hybrid nanoparticles
资金
- Natural Science Foundation of Jiangsu Normal University [16XLR046]
Poly (amidoamine) (PAMAM) dendrimers are well-defined, highly branched macromolecules with numerous active amine groups on the surface. Because of their unique properties, PAMAM dendrimers have steadily grown in popularity in drug delivery, gene therapy, medical imaging and diagnostic application. This review focuses on the recent developments on the application in PAMAM dendrimers as effective carriers for drug and gene (pDNA, siRNA) delivery in cancer therapy, including: a) PAMAM for anticancer drug delivery; b) PAMAM and gene therapy; c) PAMAM used in overcoming tumor multidrug resistance; d) PAMAM used for hybrid nanoparticles; and e) PAMAM linked or loaded in other nanoparticles.
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