期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 540, 期 1-2, 页码 50-56出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2018.01.040
关键词
Cancer; Gemcitabine; Liposome; Near-infrared (NIR)-laser; Talaporfin sodium; Triggered release
资金
- Japan Society for the Promotion of Science [16K18952]
- Grants-in-Aid for Scientific Research [16K18952] Funding Source: KAKEN
Triggered drug release is a promising strategy for delivering anticancer drugs to cancer cells and tissues. We found that liposomes co-encapsulating calcein (a water-soluble model drug and fluorescence marker) and talaporfin sodium (TPS, a water-soluble photosensitizer) released the drug upon irradiation with a near-infrared (NIR)-laser. The liposomes were composed of phospholipid (DSPC)/helper lipid (DOPE)/cholesterol/PEG-lipid (PEG2000-DSPE) at a molar ratio of 85/10/5/5 and released a large amount of drug (70% < , within 10 min) upon irradiation, but no drug in the absence of NIR-laser irradiation and/or TPS. NIR-laser-triggered drug release was facilitated by the incorporation of DOPE into the liposomes, and the amount of DOPE incorporated affected drug leakage in the absence of NIR-laser-irradiation at 37 degrees C (body temperature). Drug leakage was tuned by incorporating cholesterol into the liposomes. NIR-laser-triggered drug release from the liposomes was confirmed using the anticancer drug gemcitabine. NIR-laser treatment of liposomes co-encapsulating gemcitabine and TPS provided the maximum cytotoxic effect towards EMT6/P cells. These results suggest that these novel light sensitive liposomes may be useful for drug delivery to cancer cells.
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