Role of S-100β in stroke

The S-100 beta levels are associated with a variety of acute disorders and other chronic diseases, such as head injury, stroke, metastatic melanoma, cardiac surgery, bone fractures, burns and contusions. The serum S-100 beta levels seem to increase with the volume of tissue damage. Higher serum S-100 beta levels have been observed after brain damage or stroke. A number of studies have evidenced the clinical value of S-100 beta in the diagnosis and prognosis of stroke while the S-100 beta marker is elevated in the peripheral blood during the acute phase of stroke. However, the clinical usefulness of S-100 beta biomarker in the diagnosis and prognosis of stroke has a limitation due to its low discriminating ability in stroke diagnosis and prognosis.