期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 13, 期 -, 页码 3311-3327出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S165125
关键词
antibacterial mechanism; biocompatibility; osteogenic-related cells; orthopedic implants; silver nanoparticles; surface modification
资金
- National Natural Science Foundation of China [81772456, 51627805]
- Norman Bethune Program of Jilin University [2012216]
- Science and Technology Development program of Jilin province [20150414006GH, 20170520120JH]
- Special fund project of Jilin provincial industrial innovation [2016C037]
- Training Program of Outstanding Doctoral Student by Norman Bethune Health Science Center of Jilin University [YB201501]
- Graduate Innovation Fund of Jilin University [2017089]
Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.
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