期刊
GENES CHROMOSOMES & CANCER
卷 54, 期 7, 页码 401-408出版社
WILEY
DOI: 10.1002/gcc.22251
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资金
- Clinical Research Foundation of Tokyo Metropolitan Hospital
- Sumitomo-Shintaku Bank Foundation for Cancer Research
- Japan Leukemia Research Fund
- Grants-in-Aid for Scientific Research [24591407] Funding Source: KAKEN
We have identified a novel SPAG9-JAK2 fusion in a B-cell precursor acute lymphoblastic leukemia (ALL) with t(9;17)(p24;q21) and a poor outcome, using paired-end transcriptome sequencing. Homozygous and hemizygous deletions of CDKN2A/2B, and hemizygous deletions of PAX5, BTG1, CDK6, ADARB2, and IKZF1 were also identified by multiple ligation-dependent probe amplification and single nucleotide polymorphism array analyses. Having both a tyrosine kinase-activating rearrangement and genomic lesions affecting lymphoid transcription factors suggested that the leukemia was of the Philadelphia chromosome (Ph)/BCR-ABL1-like ALL subtype and that JAK2 inhibitors might be able to overcome this aggressive ALL with SPAG9-JAK2. (c) 2015 Wiley Periodicals, Inc.
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