期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ijms19030913
关键词
PPAR beta/delta; obesity; dyslipidaemia; type 2 diabetes mellitus; non-alcoholic fatty liver disease
资金
- Ministerio de Economia, Industria y Competitividad of the Spanish Government [SAF2015-64146-R]
- la Marato de TV3
- CIBER de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)
Research in recent years on peroxisome proliferator-activated receptor (PPAR)beta/delta indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPAR beta/delta activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPAR beta/delta regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPAR beta/delta as a treatment for human metabolic disorders.
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