期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms19061641
关键词
layer-by-layer; self-assembly; polyelectrolyte; multilayer; nanofilm; nanocoating; biomaterial; scaffold; tissue engineering
资金
- Office of the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Medical Research Program [W81XWH-17-1-0603, W81XWH1810203]
- AO Foundation
- Osteosynthesis & Trauma Care Foundation
- West Virginia National Aeronautics and Space Administration Experimental Program to Stimulate Competitive Research (WV NASA EPSCoR)
- WVU PSCoR
- WVCTSI
- NIH [2U54GM104942-02, 5P20RR016477, U57GM104942, P30GM103488, P20GM109098, P20GM103434]
- U.S. Department of Defense (DOD) [W81XWH1810203] Funding Source: U.S. Department of Defense (DOD)
Achieving surface design and control of biomaterial scaffolds with nanometer- or micrometer-scaled functional films is critical to mimic the unique features of native extracellular matrices, which has significant technological implications for tissue engineering including cell-seeded scaffolds, microbioreactors, cell assembly, tissue regeneration, etc. Compared with other techniques available for surface design, layer-by-layer (LbL) self-assembly technology has attracted extensive attention because of its integrated features of simplicity, versatility, and nanoscale control. Here we present a brief overview of current state-of-the-art research related to the LbL self-assembly technique and its assembled biomaterials as scaffolds for tissue engineering. An overview of the LbL self-assembly technique, with a focus on issues associated with distinct routes and driving forces of self-assembly, is described briefly. Then, we highlight the controllable fabrication, properties, and applications of LbL self-assembly biomaterials in the forms of multilayer nanofilms, scaffold nanocoatings, and three-dimensional scaffolds to systematically demonstrate advances in LbL self-assembly in the field of tissue engineering. LbL self-assembly not only provides advances for molecular deposition but also opens avenues for the design and development of innovative biomaterials for tissue engineering.
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