期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms19061592
关键词
major depressive disorder; brain-gut axis; microbiota-gut-brain axis; gut microbiota; psychobiotics
Major depression is one of the leading causes of disability, morbidity, and mortality worldwide. The brain-gut axis functions are disturbed, revealed by a dysfunction of the brain, immune system, endocrine system, and gut. Traditional depression treatments all target the brain, with different drugs and/or psychotherapy. Unfortunately, most of the patients have never received any treatment. Studies indicate that gut microbiota could be a direct cause for the disorder. Abnormal microbiota and the microbiota-gut-brain dysfunction may cause mental disorders, while correcting these disturbance could alleviate depression. Nowadays, the gut microbiota modulation has become a hot topic in treatment research of mental disorders. Depression is closely related with the health condition of the brain-gut axis, and maintaining/restoring the normal condition of gut microbiota helps in the prevention/therapy of mental disorders.
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