期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms19061575
关键词
obesity; type 2 diabetes; atherosclerosis; neurodegenerative disease; inflammation; macrophages; T cells; PPARs; metabolism; gender
资金
- INSERM
- Universite Cote d'Azur
- Fondation pour la Recherche Medicale (FRM) [DRM20101220437]
- French National Research Agency (ANR) [ANR-14-CE12-0008-02]
- Agence Francaise de Lutte contre le Dopage (AFLD)
- Agence Nationale de la Recherche (ANR) [ANR-14-CE12-0008] Funding Source: Agence Nationale de la Recherche (ANR)
Increasing evidence points towards the existence of a bidirectional interconnection between metabolic disease and neurodegenerative disorders, in which inflammation is linking both together. Activation of members of the peroxisome proliferator-activated receptor (PPAR) family has been shown to have beneficial effects in these interlinked pathologies, and these improvements are often attributed to anti-inflammatory effects of PPAR activation. In this review, we summarize the role of PPARs in immune cell function, with a focus on macrophages and T cells, and how this was shown to contribute to obesity-associated inflammation and insulin resistance, atherosclerosis, and neurodegenerative disorders. We address gender differences as a potential explanation in observed contradictory results, and we highlight PPAR-induced metabolic changes as a potential mechanism of regulation of immune cell function through these nuclear receptors. Together, immune cell-specific activation of PPARs present a promising therapeutic approach to treat both metabolic and neurodegenerative diseases.
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