期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/ijms19010240
关键词
estrogen receptor alpha; hypoxia-inducible factor 1; KDM4B; endocrine therapy resistance
资金
- Assisi Foundation of Memphis
- American Lebanese Syrian Associated Charities (ALSAC)
- US Public Health Service Childhood Solid Tumor Program [CA23099]
- National Cancer Institute [21766]
- American Cancer Society [130421-RSG-17-071-01-TBG]
- National Cancer Institute of the National Institutes of Health [R03CA212802]
- MRC [G0300648] Funding Source: UKRI
- Cancer Research UK [11359, 16466, 18974] Funding Source: researchfish
- Medical Research Council [G0300648] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10163] Funding Source: researchfish
Hormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor alpha and androgen receptor in breast cancer and prostate cancer, are critical to cancer cell proliferation and tumor growth. In this review we focused on the cross-talk between hormone and hypoxia pathways, particularly in breast cancer. We delineated a novel signaling pathway from estrogen receptor to hypoxia-inducible factor 1, and discussed the role of this pathway in endocrine therapy resistance. Further, we discussed the estrogen and hypoxia pathways converging at histone demethylase KDM4B, an important epigenetic modifier in cancer.
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