期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms19061706
关键词
HPV; human papillomavirus; cervical cancer; viral oncogenes; E6; E7; viral-induced cancers
资金
- National Research Foundation Singapore
- Singapore Ministry of Education under its Research Centers of Excellence initiative [R-713-006-014-271]
- National Medical Research Council (NMRC CBRG-NIG BNIG)
- Ministry of Education Academic Research Fund (MOE AcRF)
- RNA Biology Center at CSI Singapore, NUS
- Singapore Ministry of Education [MOE2014-T3-1-006]
- NUS Graduate School of Integrative Sciences and Engineering
Infection with high-risk human papillomavirus (HPV) has been linked to several human cancers, the most prominent of which is cervical cancer. The integration of the viral genome into the host genome is one of the manners in which the viral oncogenes E6 and E7 achieve persistent expression. The most well-studied cellular targets of the viral oncogenes E6 and E7 are p53 and pRb, respectively. However, recent research has demonstrated the ability of these two viral factors to target many more cellular factors, including proteins which regulate epigenetic marks and splicing changes in the cell. These have the ability to exert a global change, which eventually culminates to uncontrolled proliferation and carcinogenesis.
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