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Apolipoprotein B100 Acts as a Molecular Link Between Lipid-Induced Endoplasmic Reticulum Stress and Hepatic Insulin Resistance
Qiaozhu Su et al.
HEPATOLOGY (2009)
Improvement of Insulin Sensitivity by a Novel Drug, BGP-15, in Insulin-resistant Patients: A Proof of Concept Randomized Double-blind Clinical Trial
B. Literati-Nagy et al.
HORMONE AND METABOLIC RESEARCH (2009)
17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse
Keisuke Tokui et al.
HUMAN MOLECULAR GENETICS (2009)
Preliminary Clinical Evaluation of Toxicity and Efficacy of A New Astaxanthin-rich Haematococcus pluvialis Extract
Akira Satoh et al.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2009)
Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease
Carl Julien et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)
Determining the Effects of Lipophilic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin
Jeffrey Barry et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
Sandy D. Westerheide et al.
SCIENCE (2009)
Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model
Takayoshi Fujibayashi et al.
BMC Pulmonary Medicine (2009)
Polysaccharides-based nanoparticles as drug delivery systems
Zonghua Liu et al.
ADVANCED DRUG DELIVERY REVIEWS (2008)
Down syndrome fibroblast model of Alzheimer-related endosome pathology - Accelerated endocytosis promotes late endocytic defects
Anne M. Cataldo et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Glycosylation induces shifts in the lateral distribution of cholesterol from ordered towards less ordered domains
Katrin K. Halling et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)
Membrane-associated stress proteins:: More than simply chaperones
Ibolya Horvath et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)
Resveratrol protects primary rat hepatocytes against necrosis induced by reactive oxygen species
J. A. Rubiolo et al.
BIOMEDICINE & PHARMACOTHERAPY (2008)
Liposome-Encapsulated Curcumin Suppresses Growth of Head and Neck Squamous Cell Carcinoma In vitro and in Xenografts through the Inhibition of Nuclear Factor κB by an AKT-Independent Pathway
Dorothy Wang et al.
CLINICAL CANCER RESEARCH (2008)
Cellular and Behavioral Effects of Stilbene Resveratrol Analogues: Implications for Reducing the Deleterious Effects of Aging
James A. Joseph et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)
A mutant small heat shock protein with increased thylakoid association provides an elevated resistance against UV-B damage in Synechocystis 6803
Zsolt Balogi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones
Nobuhiro Fujikake et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS
Bernadett Kalmar et al.
JOURNAL OF NEUROCHEMISTRY (2008)
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
Urmi Bandyopadhyay et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control
Jin-Na Min et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis
Merit E. Cudkowicz et al.
MUSCLE & NERVE (2008)
Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases
Jiou Wang et al.
NEUROBIOLOGY OF AGING (2008)
Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression
Paul S. Sharp et al.
NEUROBIOLOGY OF DISEASE (2008)
HSP72 protects against obesity-induced insulin resistance
Jason Chung et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
Veena Prahlad et al.
SCIENCE (2008)
Adapting proteostasis for disease intervention
William E. Balch et al.
SCIENCE (2008)
Encapsulation of Haematococcus pluvialis using chitosan for astaxanthin stability enhancement
Prachanart Kittikaiwan et al.
CARBOHYDRATE POLYMERS (2007)
Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation
Oliver H. Voss et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Properties of Astaxanthin/Ca2+ complex formation in the deceleration of Cis/Trans isomerization
Chien-Sheng Chen et al.
ORGANIC LETTERS (2007)
Can the stress protein response be controlled by 'membrane-lipid therapy'?
Laszlo Vigh et al.
TRENDS IN BIOCHEMICAL SCIENCES (2007)
Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher antioxidant activity in vitro compared to the all-trans isomer
Xuebo Liu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line
Eniko Nagy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The small heat shock proteins and their clients
H. Nakamoto et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide
Christian Haass et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
The preparation and stability of the inclusion complex of astaxanthin with β-cyclodextrin
Xiaolin Chen et al.
FOOD CHEMISTRY (2007)
Inhibition of cell death by a novel 16.2 kD heat shock protein predominantly via Hsp90 mediated lipid rafts stabilization and Akt activation pathway
Szabolcs Bellyei et al.
APOPTOSIS (2007)
Apoptosis: A review of programmed cell death
Susan Elmore
TOXICOLOGIC PATHOLOGY (2007)
Small heat shock proteins protect against α-synuclein-induced toxicity and aggregation
Tiago Fleming Outeiro et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones
X-B. Qiu et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2006)
Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s
Zdravko Dragovic et al.
EMBO JOURNAL (2006)
Small heat shock proteins inhibit amyloid-β protein aggregation and cerebrovascular amyloid-β protein toxicity
Micha M. M. Wilhelmus et al.
BRAIN RESEARCH (2006)
Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats
S Uchida et al.
NEUROSCIENCE LETTERS (2006)
Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains
MMM Wilhelmus et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2006)
Rapamycin pre-treatment protects against apoptosis
B Ravikumar et al.
HUMAN MOLECULAR GENETICS (2006)
Rapamycin alleviates toxicity of different aggregate-prone proteins
Z Berger et al.
HUMAN MOLECULAR GENETICS (2006)
αB-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid β-peptide and β2-microglobulin
B Raman et al.
BIOCHEMICAL JOURNAL (2005)
The hyperfluidization of mammalian cell membranes acts as a signal to initiate the heat shock protein response
G Balogh et al.
FEBS JOURNAL (2005)
Macroautophagy -: a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
WH Yu et al.
JOURNAL OF CELL BIOLOGY (2005)
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
M Waza et al.
NATURE MEDICINE (2005)
Geranylgeranylacetone limits secondary injury, neuronal death, and progressive necrosis and cavitation after spinal cord injury
M Fujiki et al.
BRAIN RESEARCH (2005)
Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity
C Cleren et al.
JOURNAL OF NEUROCHEMISTRY (2005)
The small heat shock proteins and their role in human disease
Y Sun et al.
FEBS JOURNAL (2005)
The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress
AS Lee
METHODS (2005)
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
RA Nixon et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Modulation of neurodegeneration by molecular chaperones
PJ Muchowski et al.
NATURE REVIEWS NEUROSCIENCE (2005)
Oligomerization of Alzheimer's β-amyloid within processes and synapses of cultured neurons and brain
RH Takahashi et al.
JOURNAL OF NEUROSCIENCE (2004)
Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice
D Kieran et al.
NATURE MEDICINE (2004)
Hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria
T Gotoh et al.
CELL DEATH AND DIFFERENTIATION (2004)
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
J Choi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro
K Ono et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2004)
Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
G Garcea et al.
BRITISH JOURNAL OF CANCER (2004)
HSP27 but not HSP70 has a potent protective effect against α-synuclein-induced cell death in mammalian neuronal cells
A Zourlidou et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy - A comprehensive review
AS Sreedhar et al.
PHARMACOLOGY & THERAPEUTICS (2004)
Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
NJ Abbott
NEUROCHEMISTRY INTERNATIONAL (2004)
Comparison of the small heat shock proteins αB-crystallin, MKBP, HSP25, HSP20, and cvHSP in heart and skeletal muscle
N Golenhofen et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2004)
Aβ localization in abnormal endosomes:: association with earliest Aβ elevations in AD and Down syndrome
AM Cataldo et al.
NEUROBIOLOGY OF AGING (2004)
Microencapsulation of astaxanthin in a chitosan matrix
I Higuera-Ciapara et al.
CARBOHYDRATE POLYMERS (2004)
Novel regulatory factors of HSF-1 activation: facts and perspectives regarding their involvement in the age-associated attenuation of the heat shock response
I Shamovsky et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2004)
Amyloid β-peptide interactions with neuronal and glial cell plasma membrane:: Binding sites and implications for Alzheimer's disease
Y Verdier et al.
JOURNAL OF PEPTIDE SCIENCE (2004)
Heat-shock proteins as regulators of apoptosis
S Takayama et al.
ONCOGENE (2003)
Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1
J Hargitai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
α-synuclein is degraded by both autophagy and the proteasome
JL Webb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
AL Hsu et al.
SCIENCE (2003)
Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model
Y Ishii et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2003)
Mechanisms of disease: Apoptosis and caspases in neurodegenerative diseases
RM Friedlander
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase
Z Török et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Quantitating protein synthesis, degradation, and endogenous antigen processing
MF Princiotta et al.
IMMUNITY (2003)
HSP27 and HSP70 Potentially Oncogenic Apoptosis Inhibitors
Carmen Garrido et al.
CELL CYCLE (2003)
Chaperones and aging:: role in neurodegeneration and in other civilizational diseases
C Söti et al.
NEUROCHEMISTRY INTERNATIONAL (2002)
Steryl glucoside is a lipid mediator in stress-responsive signal transduction
S Kunimoto et al.
CELL STRUCTURE AND FUNCTION (2002)
Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin
A Wyttenbach et al.
HUMAN MOLECULAR GENETICS (2002)
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
B Ravikumar et al.
HUMAN MOLECULAR GENETICS (2002)
Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
PK Auluck et al.
SCIENCE (2002)
Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats
NL Lubbers et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes
JS Polakowski et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
Association of HSPB2, a member of the small heat shock protein family, with mitochondria
M Nakagawa et al.
EXPERIMENTAL CELL RESEARCH (2001)
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease
AC Allison et al.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2001)
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice
CJ Cummings et al.
HUMAN MOLECULAR GENETICS (2001)
Synechocystis HSP17 is an amphitropic protein that stabilizes heat-stressed membranes and binds denatured proteins for subsequent chaperone-mediated refolding
Z Török et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Lysosomal membrane damage in soluble Aβ-mediated cell death in Alzheimer's disease
K Ditaranto et al.
NEUROBIOLOGY OF DISEASE (2001)
Aggresomes, inclusion bodies and protein aggregation
RR Kopito
TRENDS IN CELL BIOLOGY (2000)
Apoptosis in neurodegenerative disorders
MP Mattson
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)
Antioxidant activity of polar carotenoids including astaxanthin-β-glucoside from marine bacterium on PC liposomes
Y Matsushita et al.
FISHERIES SCIENCE (2000)
Modulation of Akt kinase activity by binding to Hsp90
S Sato et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Effect of subchronic bimoclomol treatment on vascular responsiveness and heat shock protein production in spontaneously hypertensive rats
A Jednákovits et al.
LIFE SCIENCES (2000)
Correlation of β-amyloid aggregate size and hydrophobicity with decreased bilayer fluidity of model membranes
JJ Kremer et al.
BIOCHEMISTRY (2000)
Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90
P Pandey et al.
EMBO JOURNAL (2000)
ER stress response: Getting the UPR hand on misfolded proteins
RY Hampton
CURRENT BIOLOGY (2000)
Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer's disease and Down syndrome -: Differential effects of APOE genotype and presenilin mutations
AM Cataldo et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Cell death mechanisms in Parkinson's disease
KA Jellinger
JOURNAL OF NEURAL TRANSMISSION (2000)
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