期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms19061687
关键词
spa therapy; mud therapy; hydrotherapy; hormesis; immune response; inflammation; oxidative stress; heat shock proteins; pain; rheumatic diseases
资金
- Gobierno de Extremadura-FEDER [GR 15041]
- Formacion del Profesorado Universitario (FPU) from the Ministerio de Educacion, Cultura y Deporte, Spain [FPU15/02395]
Balneotherapy is a clinically effective complementary approach in the treatment of low-grade inflammation- and stress-related pathologies. The biological mechanisms by which immersion in mineral-medicinal water and the application of mud alleviate symptoms of several pathologies are still not completely understood, but it is known that neuroendocrine and immunological responsesincluding both humoral and cell-mediated immunityto balneotherapy are involved in these mechanisms of effectiveness; leading to anti-inflammatory, analgesic, antioxidant, chondroprotective, and anabolic effects together with neuroendocrine-immune regulation in different conditions. Hormesis can play a critical role in all these biological effects and mechanisms of effectiveness. The hormetic effects of balneotherapy can be related to non-specific factors such as heatwhich induces the heat shock response, and therefore the synthesis and release of heat shock proteinsand also to specific biochemical components such as hydrogen sulfide (H2S) in sulfurous water and radon in radioactive water. Results from several investigations suggest that the beneficial effects of balneotherapy and hydrotherapy are consistent with the concept of hormesis, and thus support a role for hormesis in hydrothermal treatments.
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