期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 96, 期 3, 页码 507-513出版社
CELL PRESS
DOI: 10.1016/j.ajhg.2015.01.016
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资金
- Stockholm County Council
- Karolinska Institutet
- Kronprinsessan Lovisa
- Frimurare Barnhuset i Stockholm
- Cancer Research Foundations of Radiumhemmet
- Swedish Childhood Cancer Foundation
- Harald och Greta Jeanssons Foundation
- Nilsson-Ehle Foundation
- Erik Ronnberg Foundation
- Swedish Research Council
- Swedish Brain Foundation (Hjarnfonden)
- Karolinska Institutet research funds
Through a multi-center collaboration study, we here report six individuals from five unrelated families, with mutations in KAT6A/MOZ detected by whole-exome sequencing. All five different de novo heterozygous truncating mutations were located in the C-terminal transactivation domain of KAT6A: NM_001099412.1: c.3116_3117 delCT, p.(Ser1039*); c.3830_3831insTT, p.(Arg1278Serfs*17); c.3879 dupA, p.(Glu1294Argfs*19); c.4108G>T p.(Glu1370*) and c.4292 dupT, p.(Leu1431Phefs*8). An additional subject with a 0.23 MB microdeletion including the entire KAT6A reading frame was identified with genome-wide array comparative genomic hybridization. Finally, by detailed clinical characterization we provide evidence that heterozygous mutations in KAT6A cause a distinct intellectual disability syndrome. The common phenotype includes hypotonia, intellectual disability, early feeding and oromotor difficulties, microcephaly and/or craniosynostosis, and cardiac defects in combination with subtle facial features such as bitemporal narrowing, broad nasal tip, thin upper lip, posteriorly rotated or low-set ears, and microretrognathia. The identification of human subjects complements previous work from mice and zebrafish where knockouts of Kat6a/kat6a lead to developmental defects.
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