期刊
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
卷 15, 期 2, 页码 170-175出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijms.22513
关键词
AURKA polymorphisms; Hepatocellular carcinoma; Single nucleotide polymorphism; Susceptibility
资金
- Ministry of Science and Technology of Taiwan [MOST 106-2320-B-039-005]
- China Medical University Hospital [DMR-105-062]
Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. AURKA (aurora kinase A) is a mitotic serine/threonine kinase that functions as an oncogene and plays a critical role in hepatocarcinogenesis. We report on the association between 4 single nucleotide polymorphisms (SNPs) of the AURKA gene (rs1047972, rs2273535, rs2064836, and rs6024836) and HCC susceptibility as well as clinical outcomes in 312 patients with HCC and in 624 cancer-free controls. We found that carriers of the TT allele of the variant rs1047972 were at greater risk of HCC compared with wild-type (CC) carriers. Moreover, carriers of at least one A allele in rs2273535 were less likely to progress to stage III/IV disease, develop large tumors or be classified into Child-Pugh class B or C. Individuals with at least one G allele at AURKA SNP rs2064863 were at lower risk of developing large tumors or progressing to Child-Pugh grade B or C. Our results indicate that genetic variations in the AURKA gene may serve as an important predictor of early-stage HCC and be a reliable biomarker for the development of HCC.
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