期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 308, 期 1, 页码 228-236出版社
ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2017.10.014
关键词
LC3-associated phagocytosis; Fungi; Bacteria; Parasites; Evasion
资金
- Deutsche Forschungsgemeinschaft [SPP1580, ZA533 7/1, ZA533 7/2]
Phagocytosis is essential for uptake and elimination of pathogenic microorganisms. Autophagy is a highly conserved mechanism for incorporation of cellular constituents to replenish nutrients by degradation. Recently, parts of the autophagy machinery above all microtubule-associated protein 1 light chain 3 (LC3) were found to be specifically recruited to phagosomal membranes resulting in phagosome-lysosome fusion and efficient degradation of internalized cargo in a process termed LC3-associated phagocytosis (LAP). Many pathogenic bacterial, fungal and parasitic microorganisms reside within LAP-targeted single-membrane phagosomes or vacuoles after infection of host cells. In this minireview we describe the state of knowledge on the interaction of pathogens with LAP or LAP-like pathways and report on various pathogens that have evolved strategies to circumvent degradation in LAP compartments.
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