期刊
GENES & DEVELOPMENT
卷 29, 期 5, 页码 467-482出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.256396.114
关键词
Wilms' tumor; Wt1; beta-catenin; kidney development; miRNA; nephron progenitor cells
资金
- University College London (UCL) Grand Challenges Scheme
- Olivia Hodson fund
- European Commission FP7 project [270089]
- National Institute for Health Research Great Ormond Street Hospital UCL Biomedical Research Centre
- Cancer Research UK [C1188/A4614]
- Great Ormond Street Hospital Children's Charity
- Children with Cancer [113]
- European Commission FP7 project European Network for Cancer Research in Children and Adolescents (ENCCA) [261474]
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/J004316/1]
- BBSRC [BBS/E/D/20221657] Funding Source: UKRI
- MRC [MR/M010341/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20221657] Funding Source: researchfish
- Cancer Research UK [17297] Funding Source: researchfish
- Great Ormond Street Hospital Childrens Charity [W1025, V1405, W1090] Funding Source: researchfish
- Medical Research Council [MR/M010341/1] Funding Source: researchfish
Wilms' tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors morphologically resemble embryonic kidneys with a disrupted architecture and are associated with undifferentiated metanephric precursors. Here, we discuss genetic and epigenetic findings in Wilms' tumor in the context of renal development. Many of the genes implicated in Wilms' tumorigenesis are involved in the control of nephron progenitors or the microRNA (miRNA) processing pathway. Whereas the first group of genes has been extensively studied in normal development, the second finding suggests important roles for miRNAs in general and specific miRNAs in particular in normal kidney development that still await further analysis. The recent identification of Wilms' tumor cancer stem cells could provide a framework to integrate these pathways and translate them into new or improved therapeutic interventions.
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