期刊
GENES & DEVELOPMENT
卷 29, 期 9, 页码 889-897出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.261974.115
关键词
gene expression; mRNA processing; poly(A) site recognition
资金
- National Institutes of Health (NIH) [GM090056, CA177651]
- American Cancer Society [RSG-12-186]
- NIH [GM28983]
The key RNA sequence elements and protein factors necessary for 3' processing of polyadenylated mRNA precursors are well known. Recent studies, however, have significantly reshaped current models for the protein-RNA interactions involved in poly(A) site recognition, painting a picture more complex than previously envisioned and also providing new insights into regulation of this important step in gene expression. Here we review the recent advances in this area and provide a perspective for future studies.
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