期刊
GENES & DEVELOPMENT
卷 29, 期 21, 页码 2219-2224出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.269498.115
关键词
TERT; chromatin; monoallelic; noncoding mutations; promoter; telomerase
资金
- National Health and Medical Research Council of Australia
- National Institutes of Health [R01 GM099705, R37 CA43460, R01 CA091846, P30 CA046934]
- Virginia and D.K. Ludwig Fund for Cancer Research
- Lustgarten Foundation for Pancreatic Cancer Research
- Sol Goldman Center for Pancreatic Cancer Research
Somatic mutations in the promoter of the gene for telomerase reverse transcriptase (TERT) are the most common noncoding mutations in cancer. They are thought to activate telomerase, contributing to proliferative immortality, but the molecular events driving TERT activation are largely unknown. We observed in multiple cancer cell lines that mutant TERT promoters exhibit the H3K4me2/3 mark of active chromatin and recruit the GABPA/B1 transcription factor, while the wild-type allele retains the H3K27me3 mark of epigenetic silencing; only the mutant promoters are transcriptionally active. These results suggest how a single-base-pair mutation can cause a dramatic epigenetic switch and monoallelic expression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据