期刊
GENERAL HOSPITAL PSYCHIATRY
卷 37, 期 4, 页码 365-367出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.genhosppsych.2015.03.017
关键词
First-episode schizophrenia; Blood pressure; Lipids; Childhood trauma; Early life stress
类别
资金
- National Science Center [DEC-2011/03/N/NZ5/00248]
- START scholarship by Foundation for Polish Science
Objective: It has repeatedly been found that early-life traumatic events may contribute to metabolic dysregulation. Therefore, the aim of this study was to investigate the association between the history of childhood trauma and cardiovascular risk factors in first-episode schizophrenia (FES) patients. Method: The history of childhood traumawas assessed using the Early Trauma Inventory Self Report-Short Form (ETISR-SF) in 83 FES patients. Based on the ETISR-SF, patients were divided into those with positive and negative history of childhood trauma: FES(+) and FES(-) patients. Serum levels of fasting glucose lipids, homocysteine, vitamin B12 and folate, as well as anthropometric parameters and resting systolic and diastolic blood pressure (SBP and DBP) were measured. Results: The history of childhood trauma was associated with higher low-density lipoprotein (LDL) levels, SBP and DBP after covarying for age, gender, body mass index, education and chlorpromazine equivalent. There were significant correlations between scores of distinct ETISR-SF subscales and LDL, high-density lipoprotein, SBP, DBP and the number of metabolic syndrome criteria. Conclusions: Results of this study indicate that traumatic events during childhood might be related to higher resting blood pressure and higher LDL levels in adult FES patients. (C) 2015 Elsevier Inc. All rights reserved.
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