期刊
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
卷 38, 期 1, 页码 S123-S131出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PGP.0000000000000488
关键词
Endometrial carcinoma; p53; TP53; Immunohistochemistry; Interpretation
资金
- Calgary Laboratory Services Research [RS14-525i]
- MSK Cancer Center Support Grant of the National Institutes of Health/National Cancer Institute [P30CA008748]
P53 immunohistochemistry has evolved into an accurate surrogate reflecting the underlying TP53 mutation status of a tumor, and has utility in the diagnostic workup of endometrial carcinomas. Recent work predominantly carried out in tubo-ovarian high-grade serous carcinoma has revealed 4 main patterns of p53 staining (normal/wild-type, complete absence, overexpression, and cytoplasmic); the latter 3 patterns are variably termed abnormal/aberrant/mutation-type and are strongly predictive of an underlying TP53 mutation. The aim of this review is to provide practical advice to pathologists regarding various aspects of p53 immunohistochemical staining. These include laboratory methods to optimize staining, a description of the different patterns of staining, advice regarding the interpretation, and reporting of p53 staining and practical uses of p53 staining in endometrial carcinoma diagnosis. Illustrations are provided to aid in the interpretational problems.
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