期刊
GENOME BIOLOGY
卷 15, 期 9, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s13059-014-0473-4
关键词
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资金
- Rackham Predoctoral Fellowship
- Center of Computation Biology and Medicine at University of Michigan
Intra-tumor heterogeneity reflects cancer genome evolution and provides key information for diagnosis and treatment. When bulk tumor tissues are profiled for somatic copy number alterations (sCNA) and point mutations, it may be difficult to estimate their cellular fractions when a mutation falls within a sCNA. We present the Clonal Heterogeneity Analysis Tool, which estimates cellular fractions for both sCNAs and mutations, and uses their distributions to inform macroscopic clonal architecture. In a set of approximately 700 breast tumors, more than half appear to contain multiple recognizable aneuploid tumor clones, and many show subtype-specific differences in clonality for known cancer genes.
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