期刊
GENE
卷 557, 期 1, 页码 1-10出版社
ELSEVIER
DOI: 10.1016/j.gene.2014.11.051
关键词
Ubiquitin; Ubiquitin protein ligases; NEDD4 family; Epithelial sodium channel (ENaC); Voltage-gated sodium channels (Na(v)s); Hypertension
资金
- National Health and Medical Research Council (NHMRC) [1020755, 1059393, 1002863]
- University of Adelaide International post-graduate research scholarship
- Mary Overton Early Career Research Fellowship
- National Health and Medical Research Council of Australia [1059393] Funding Source: NHMRC
NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover. Several of the NEDD4-2 substrates include ion channels, such as the epithelial and voltage-gated sodium channels. Given the critical function of NEDD4-2 in regulating membrane proteins, this ligase is essential for the maintenance of cellular homeostasis. In this article we review the biology and function of this important ubiquitin-protein ligase and discuss its pathophysiological significance. (C) 2014 Elsevier B.V. All rights reserved.
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