期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 62, 期 1-3, 页码 257-264出版社
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.170323mm
关键词
chicken; embryology; transgenic; genetic modification; gene editing; fluorescent proteins
资金
- Institute Strategic Grant from the Biotechnology and Biological Sciences Research Council [BB/J004316/1, BB/P013732/1]
- Fight for Sight
- Roslin Foundation
- British Society for Surgery of the Hand
- BBSRC [BB/E011276/2]
- Wellcome Trust [094182/Z/10/Z]
- Medical Research Council [MR/L018160/1]
- BBSRC [BBS/E/D/20221657, BBS/E/D/10002071, BBS/E/D/20221658, BBS/E/D/20320000] Funding Source: UKRI
- MRC [MR/L018160/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20320000, BBS/E/D/20221658, BB/E011276/2] Funding Source: researchfish
After decades of research investment, techniques for the robust and efficient modification of the chicken genome are now with us. The biology of the chicken has provided many challenges, as have the methods by which transgenes can be readily, stably and functionally integrated into the genome. Now that these obstacles have been surmounted and the chicken has been 'updated' to a cutting-edge modern model organism, a future as a central and versatile model in developmental biology beckons. In this review, we describe recent advances in genetic modification of the chicken and some of the many transgenic models developed for the elucidation of the mechanisms of embryogenesis.
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